These workers had prick test reactivity to B-subtilis alcalase and maxatase and exhibited both immediate and lape phase asthmatic response following inhalation challenges. A study performed in the United States on 38 detergent workers identified immediate onset upper respiratory tract, nasal and ocular symptoms in 11 workers and no respiratory symptoms in 25 workers, which often begins 3-8 hours after leaving work. (Franz et al., Clinical, immunologic, and physiologic observation in factory workers exposed to B-subtilis enzyme dust, Journal of Allergies 47; 170-179}.
There is data in the literature associating exposure to bacillus subtilis products and respiratory disease as well as rhino conjunctivitis, (Kaner et al., Contact Dermatitis 2001, 45: 49-51, Flindt et al., Occupational Medicine, Volume 52, 2002).
The best known species of Lagenidium is Lagenidium giganteum, a parasite of mosquito larvae used in biological control of mosquitoes. Two different species cause disease exclusively in dogs: L. caninum and L. karlingii. Lagenidiosis is found in the southeastern United States in lakes and ponds. It causes progressive skin and subcutaneous lesions in the legs, groin, trunk, and near the tail. The lesions are firm nodules or ulcerated regions with draining tracts. Regional lymph nodes are usually swollen. Spread of the disease to distant lymph nodes, large blood vessels, and the lungs may occur.[7] An aneurysm of a great vessel can rupture and cause sudden death.[17] L. caninum is the more aggressive species and is more likely to spread to other organs than L. karlingii.[2
