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PATHOGENS CROSSING OVER TO HUMANS FROM PLANTS, INSECTS AND SOIL / MANY ARE USED IN BIO-CONTROL PRODUCTS

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HAZARD!!!!!

 

Do you work in the agricultural arena; in the farm field and exposed to plant diseases (bacteria fungi etc.? Do you handle biological pesticides, insecticides, fungicides etc? Are you exposed to biological control products in a research laboratory? Are you a crop duster or are exposed to bio-control products that fill the crop duster tanks?

If the answer is yes to any of the above, then please read on. You could be at risk of serious health hazards - which may lead to illness and/or diseases. These may not show up for years.

In the case of those in the direct line of fire, the laboratory employee is at paticular risk.

A 'then' college student (who wanted outside lab experience) had accepted a temporary position as an Assistant Researcher at the microbial research and development company Agraquest, Inc. in Davis California.  Years later, he still continues to get sinus infections. Read;  NON REPORTED Occupational Exposures & Illnesses Sustained From Employment At Agraquest, Inc. A Microbial Biotechnology Research & Development Company - Founder Pamela Gail Marrone


The state of California Department of Health was 'owner' of fungus Lagenidium giganteum, that was the "active ingredient" in the Assistant Researcher's project, Laginex.

See PAN Pesticides Database - Pesticide Products; Product Name: Lagenidium giganteum mycelium & oospores

After he realized the connections to Agraquest and his repeated infections, he filed for Worker's compensation on October 3, 2003.  On October 24, 2003 the California Department of Health was no longer the owner of the fungus as it had been since 1991 (see link Product Name: Lagenidium giganteum mycelium & oospores)

Not only was Lagenidium deemed to be a new human oomycete in 2004 (Amy Grooters), but now, described on the CDC's website, the same project the Assistant Researcher worked on, Laginex is listed in the research paper, Lagenidium giganteum Pathogenicity in Mammals.

QUOTES:

"The emergence of heat-tolerant strains of L. giganteum pathogenic to lower animals and humans is of environmental and public health concern."

"In 1995, the US Environmental Protection Agency registered L. giganteum under the trade name Laginex as a biocontrol agent (13) but later deregistered it at the request of the manufacturer (http://www.gpo.gov/fdsys/pkg/ FR-2011-09-28/pdf/2011-24832.pdf)."

JPG.bioBROCHURE

 

State of California

Co-Registrant

with PRIVATE

California Biotech company

on

California Strain of fungus

~Lagenidium   giganteum

**L. giganteum is the SAME fungus that Laboratory Assistant Researcher's 'primary' project was when after only 5 months & 9 days on the job the biotech employee became violently ill with bloody pus draining from his nose. 3 days later the left half of his face and teeth were numb. Within 1 week of becoming violently ill; the injured/ill biotech employee was scheduled for what would become the 1st of 4 MAJOR sinus surgeries.

What followed? Breakdown of immune system & numerous bacteria and fungi medically identified in blood work, sinus & sputum cultures; ALL RELATED to occupational exposure from employer's patents, products and experiments.

Microorganisms, which are NATURALLY found, in plant disease, insect diseases and soils

CROSS-OVER to humans.  Many are being (or have been) used in bio-control products on

agricultural crops, ornamentals and used for insect control.  Some are also being as plant

growth stimulators and seed treatments.

 

 

Dr. Anne K. Vidaver gave a presentation; "Cross-infective microbes: from plants to

humans" during the 2006 "Microbial Biopesticides and Transgenic Insecticides -

Enhancing Regulatory Communication" workshop in Washington DC at the University of

California Center on Regulatory Communication in 2006, before representatives from

numerous Federal and State agencies and Universities.  It is more than evident she was

desperately trying to get everyone to pay attention to the human health hazards of exposure

to plant pathogens but also that many of these plant pathogens are being used as biocontrol

products.  Her talk  SEEMS TO HAVE FALLEN ON DEAF EARS.  Some of what she had to

say is listed below:

    • "So, you might want to know why do we have this topic for this workshop. Well, because there are some organisms that are used as microbial pesticides or prospective microbial pesticides, and in my experience, plant pathologist don't know about some of these microbes and the medical community conversely does not. And it's unfortunate that with all the people ... regulatory agencies, we're missing a few internationally; hopefully learn from what I plan to say, mainly the Food and Drug Administration nationally needs help."
  • "I'm going to talk about some illustrations of plants; plant/human cross infections and use those as examples, and then I'll talk about what this actually could mean, both to the scientific community and to the regulated community and challenges for regulators as well ... so."
    • "More and more bacteria by the way are being reported to be the cause of some chronic diseases."
    • "The prospective virtue of fungi; which I'll talk more about later, is that in some ways they are more desirable as microbial control agents; but I'll say more about why that is."
      "Now, the majority of the diseases that I'm going to talk about in humans are rare; but, there will be a few that are not so rare; and I'll try to point those out when we come to those. And obviously, for anybody in the regulatory arena, this causes at least a plausible thought, but I'll indicate what some of the challenges are with this."
  • "OK, so first of all, what am I talking about? The terms are not yet agreed upon what this means. You can talk about organisms that are cross infected; mainly go to from plants to humans. You can also call them cross-over pathogens and you can also call them Cross, or inter-kingdom pathogens, and Dr. Tauxe from the CDC invented the term as far as I know. Phytoses to force on with zoo-onoces, that is organisms that go from animals to people. What they are not; is they're not overlapped pathogens in the select agent list with the FDA and AMA."
    • "One of the important questions for people in ... the more we know in the way; the less we know is actually do we classify organisms? I mean this is a human endeavor but we have to do this in order to communicate."
  • "One place I think that there's something missing, and it is not perhaps straight forward to talk about, is that we could have an interdisciplinary program across agencies, there's certainly interagency programs already in many areas, but we do not have any, as far as I know, that incorporate USDA and NIH [inaudible], certainly in this area of cross-infective microorganisms."
    • " I dare say the medical community has no idea that some of these are really a problem in plants and the plant community has no idea that these are problems in medicine."
  • " Actually, the question really for the medical community and even for the plant community is, are we talking about the same organism? In many cases, that's still very much the question."
    • "And so, then how we do this is still a very fluid field, and this is good; but it's a very challenging area then for anyone who is in the regulatory arena. "
    • " This is also then true in terms of nanoclature. What are you going to name an organism? How are you going to identify it, and then how are you going to characterize any group of individuals [inaudible] by rank?"
  • " And then for species; at least for the present time, for bacteria you have a species being defined with at least 70% related misbind DNA."
    • "Homology: Well, some microbial geneticists believe that this is, in again, inappropriate maybe with what we know, but no one has yet come up with something that is actually being received well as an alternative, so this is still a challenge."
    • "What is the species? And I'm not sure even for the fungi that there is agreement on what is the species; and I don't know about some of the other organisms as well."
    • "And then for defining a strain that you would actually use and that you would worry about stability, we're talking about the descendants of a single isolation, your culture."
    • "Then there's the question of what do you do about the host responses. How do you measure the population; even of plants or people or animals as the case may be, because we are not in a scattered population in any of those categories."
  • " We need to know a lot more about induced and innate immunity; simply to be able to combat all these challenging organisms that are multiplying and changing at a faster rate than we are. "
    • "A DNA shuffling is going on often ; that is the rearrangement of genomes and how will this be actually seen by regulatory agencies is not clear. It could be [inaudible] that may come out in this workshop."
  • "Our model system analysis appropriate; it can all be complex depending on what you're looking at it and many people that are on both sides of the fence, but in any case this is a challenge; both for the regulated community and the regulatory system."

Dr. Anne K. Vidaver's Abstract of CROSS-INFECTIVE MICROBES: FROM PLANTS TO

HUMANS states;

"Microorganisms that infect and cause disease in both plants and people are uncommon but increasing in frequency of isolation. These cross-infective microorganisms are more insidious than those simply transmitted to humans by contact or consumption of plants. Currently 22 bacterial taxa and 38 fungal taxa have been reported as causing ‘phytoses’. Several examples of bacterial and fungal diseases of plants and corresponding human disease will be presented. Questions that arise include accuracy of systematics analyses, role and similarity of virulence factors, genomic and pathogenicity islands and antimicrobial resistance. Newer biological techniques such as synthetic biology, illustrated by the construction of new viruses and DNA shuffling or intragenomic reconstruction, complicate oversight and regulatory action. Regulatory challenges among presumed equivalent taxa among plant and medical communities include definition and assessment of risk groups, permitting for interstate transport and differential perspective on the use and formulation of regulatory agency guidance documents. Assessment of alternatives for microbial pesticide niche markets will be presented. Potential interagency programs on cross-over pathogens will be discussed. The major challenge for agencies with regulatory responsibility for microbial biopesticides is the assessment and accuracy of taxa and scope of both natural and modified biological variations that may be used and their genomic stability. Management of cross-infective diseases of both plants and animals will require more interdisciplinary research and cooperative agency interactions."

Although NUMEROUS biocontrol agents are on the market presently (or were on the market and have since been cancelled) there remains the question as to how many agricultural workers and those employed in biotechnology research and development laboratories around the world have no idea just what they have been exposed to that have made them ill and/or sustained terrible diseases because of occupational exposure/s to the bacteria and fungi on the following list?  This does not take into account the question as well as to how many family members have medical problems because their loved one carried home microscopic bacteria and fungi on their clothes, their shoes and anything that was brought home from the workplace environment?

In Humans / Animals & Cross-Infections from Plants, Soils and Insects you will find a

detailed list of the following bacteria and fungi that cross-infect humans). Many of these are

the "active ingredient" in bio-control products.

 

***The check mark '' indicates the connection of the bacteria and fungi to bio-control products

Absidia
Acinetobacter
Acremonium
Agrobacterium
Alternaria
Aspergillus
Aureobasidium

Bacillus
Bipolaris
Blastomyces
Botryodiplodia

Burkholderia
Chaetomium
Cladophialophora
Cladosporium 
Clostridium
Cochilobolus
Coniothyrium
Corynespora

Cryptococcus
Curtobacterium
Curvularia
Cylindrocapron
Dickeya
Diplodia
Drechslera
Enterobacter

Enterobacter
Enterococcus
Erwinia

Escherichia Coli
Exophiala
Exserohilim
Filobasidiella
Fusarium     
Fusicoccum
Gibberella
Glomerella
Haematonectria
Hendersonula
Histoplasma
Hortaea
Hypocrea
Hyphomyces
Klebsiella

Lagenidium
Lasiodiplodia
Lecythophora
Legionella
Lewia
Microbacterium
Mucor

Muscodor
Mycobacterium

Nattrassia
Paecilomyces
Pantoea
Pectobacterium

Penicillium
Phaeoacremonium
Phaeoannelloymces
Phialophora

Phoma
Pleurostomophora
Pseudocochliobolus

Pseudomomas
Pythium
Rathayibacter

Rhizobium
Rhizopus
Schizophyllum

Scytalidium
Serratia
Setosphaeria
Sporothichum
Sporothrix
Staphylococcus
Stenotrophomonas

Streptomyces
Togninia

Trichoderma
Xanthomona

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

REFERENCED BY:

1. Acinetobacter Infection by L. Silvia Munoz-Price, M.D., and Robert A. Weinstein, M.D.; New England Journal of Medicine

2. Isolation of Acinetobacter from Soil and Water; Paul Baumann1 Department of Bacteriology and Immunology,University of California, Berkeley, California 94720

3. page 601: STUDIES ON CULTURED AND UNCULTURED MICROBIOTA OF WILD CULEX QUINQUEFASCIATUS MOSQUITO MIDGUT BASED ON 16S RIBOSOMAL RNA GENE ANALYSIS; Am. J. Trop. Med. Hyg., 70(6), 2004, pp. 597–603

4. National Institute of Health: Tissues of the Mosquito Vector Aedes albopictus

5. MARCH 24-26, 2004; Focus on Fungal Infections 14,New Orleans, Louisiana

6. AgraQuest seeks $5 million infusion; Sacramento Business Journal - December 5, 1997 by Lynn Graebner Staff Writer

7. FEMS Microbiol Rev, Apr;31(3):239-277; Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps?

8.  BIOLOGICAL SAFETY - Principles and Practices; LABORATORY, GROWTH CHAMBER AND GREENHOUSE MICROBIAL SAFETY: PLANT PATHOGENS AND PLANT-ASSOCIATED MICROORGANISMS OF SIGNIFICANCE TO HUMAN HEALTH by ANNE K VIDAVER, SUE A. TOLIN, AND PATRICIA LAMBRECHT - 4th edition

9. “Cross-infective microbes: from plants to humans” by Anne Vidaver;
Enhancing Regulatory Communication Workshop November 2006

 
 
 
 
 

16. US NUS National Library of Medicine National Institutes of Health; J Am Mosq Control Assoc. 2007;23(2 Suppl):50-7. Oomycetes: Lagenidium giganteum.; Kerwin JL.; Source Department of Biological Chemistry, School of Medicine University of California, Los Angeles, CA 90095, USA.

 


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